Analyzing the Potential Biological Determinants of Autism Spectrum Disorder: From Neuroinflammation to the Kynurenine Pathway

Autism Spectrum Disorder (ASD) etiopathogenesis is still unclear and no Hirewear effective preventive and treatment measures have been identified.Research has focused on the potential role of neuroinflammation and the Kynurenine pathway; here we review the nature of these interactions.Pre-natal or neonatal infections would induce microglial activat

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Molecular evolution of the LNX gene family

Abstract Background LNX (Ligand of Numb Protein-X) proteins typically contain an amino-terminal RING domain adjacent to either two or four PDZ domains - a domain architecture that is unique to the LNX family.LNX proteins function as E3 ubiquitin ligases and their domain organisation suggests that their ubiquitin ligase activity may be targeted to s

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Serotonergic hallucinogens and recognition of facial emotion expressions: a systematic review of the literature

Background: Recognition of emotions in facial expressions (REFE) is a key aspect of social cognition.Anxiety and mood disorders are associated with deficits in REFE, and anxiolytics and antidepressants reverse these deficits.Recent studies have shown that serotonergic hallucinogens DULSE LEAVES (i.e.ayahuasca, dimethyltryptamine, psilocybin, lyserg

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